In this episode we discuss:

How the largest body of evidence cited in favor of hormesis actually doesn’t support it at all


Why caloric restriction is NOT responsible for slowing aging and extending lifespan (and what is actually responsible)


The many factors that confound the calorie restriction research (including differences between organisms, poor research design, amino acid restriction, PUFA, endotoxin, and more)


 
Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy
 
Click here to check out the show notes: https://jayfeldmanwellness.com/ep-76-why-caloric-restriction-is-not-responsible-for-lifespan-extension-hormesis-part-2/ 


 
Timestamps:
3:36 – the physiology of hormesis and the general support for hormesis
12:54 – outlining the problems with hormesis
18:51 – how differences between organisms confound the caloric restriction research 
37:34 – the problem with using proxy markers to evaluate health effects and the importance of context
48:20 – how differences between organisms confound the caloric restriction research (cont.)
51:58 – how hydration status and macronutrient ratios confound the caloric restriction research
55:57 – how the myopic hormetic view leads to the ignorance of many confounding variables
1:02:00 – how the restriction of particular amino acids, ad libitum feeding, and a refined diet confound the caloric restriction research
1:11:58 – how PUFA confounds the caloric restriction research
1:30:09  – how endotoxin and gut health confound the caloric restriction research