GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/setpoint

1:55 - Follow Melanie On Instagram To See The Latest Moments, Products, And #AllTheThings! @MelanieAvalon

2:05 - IF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group At Facebook.com/groups/paleoOMAD For A Weekly Episode GIVEAWAY, And To Discuss And Learn About All Things Biohacking! All Conversations Welcome!

2:30 - FOOD SENSE GUIDE: Get Melanie's App At Melanieavalon.com/foodsenseguide To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More!

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6:40 - Jonathan's Personal History

11:35 - Why Do People Gain Or Lose Weight?

13:10 - The Global Economic Impact Of Diabetes

14:50 - What Happens With Calories That We Eat?

16:45 - The Calorie Is A Measure Of Energy Alone

18:00 - Why Does The Body Burn Or Store Calories?

19:50 - Dietary Induced Thermogenesis

20:00 - N.E.A.T. (Non-Exercise Activity Thermogenesis)

21:40 - DRY FARM WINES: Low Sugar, Low Alcohol, Toxin-Free, Mold- Free, Pesticide-Free, Hang-Over Free Natural Wine! Use The Link dryfarmwines.com/melanieavalon To Get A Bottle For A Penny!

23:20 - Perceived Rate Of Exertion

24:20 - Eat Less, Move Less

24:30 - What Is The Stress Response To A Crash Diet?

25:10 - Long Term Outcomes Of Crash Dieting

26:15 - Yo-Yo Dieting And The Extracellular Matrix

27:00 - Defining The "Set Point"

29:55 - How Do We Get Our Set Point? How Does It Change?

33:00 - Obesity As A Disease State 

34:00 - The Quality Of The Food We Eat

35:00 - The Overconsumption Of Food

36:40 - Hormone "Clogging"

39:35 - Parabiotic Studies

40:45 - The Communication Between Brain, Gut, And Hormones

43:40 - The Genetic Component

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47;55 - The Pervasive Shame In Being "Over-Fat" In Society

48:30 - SANESolution

50:25 - Evaluating Foods On A Spectrum For Optimal Health

52:10 - The SANE Food Groups

55:30 - What About Lower Fat Or Lower Carb?

57:05 - Metabolic Conditioning

59:10 - The Randall Cycle 

59:25 - The Myth Of Exercise

1:02:50 - Mechanical Removal Of Fat Cells