25 min listen
PREVIEW Aliquot #3: Q&A Mashup - Fasting
ratings:
Length:
28 minutes
Released:
Feb 25, 2021
Format:
Podcast episode
Description
This month’s Aliquot Preview episode is a collection of clips that covers a range of topics related to fasting, including associated mechanisms of healthspan and longevity, health benefits, and when and how to break the fast. In this episode, you'll discover: 00:00:00 - Intermittent fasting caused an increase in bacterial richness in the gut microbiome that correlated with increased T-regulatory immune cells. 00:01:36 - Fasting mimicking diet, the ketogenic diet and autoimmune diseases 00:02:58 - Autophagy during fasting 00:04:47 - It takes 5 days of water fasting in humans in order to reduce IGF-1 levels 50%. 00:07:00 - When is autophagy occuring during a fast? 00:09:55 - Sensitivity of biomarkers of inflammation and autophagy 00:12:37 - Resveratrol is a caloric restriction or fasting mimetic compound that decreases protein acetylation via enzymes called sirtuins. 00:13:42 - Spermidine is a fasting mimetic compound found in foods like natto that directly inhibit protein acetylation. 00:14:25 - Spermidine has been shown to prolong lifespan in animal studies via increasing autophagy. 00:15:05 - Spermidine has been shown to improve memory capacity and heart function in animal studies. 00:16:51 - Aerobic exercises in a fasting state induces autophagy quicker than in a fed state. 00:21:00 - Mild caloric restriction for over 6 years induces autophagy. 00:23:35 - Rhonda discusses proxies that can be used for detecting autophagy. 00:25:15 - Intermittent fasting, prolonged fasting and healthspan. 00:28:02 - What we know about the minimal fasting time it takes to induce autophagy and apoptosis. 00:30:25 - After a fast, refeeding causes stem cells to replenish the lost cells and rejuvenate tissues. 00:33:35 - Comparing and contrasting a ketogenic diet with prolonged fasting. 00:34:02 - The most effective way to induce autophagy is exercise and prolonged water fasts. 00:37:33 - Rhonda compares the rejuvenation effect of time-restricted eating vs prolonged fasting vs fasting mimicking diet. 00:41:16 - Rhonda's thoughts on coffee breaking a fast. 00:48:44 - Calorie-free substances during a time-restricted eating window vs. a prolonged fast. 00:52:29 - Supplements and other medications outside of a time-restricted eating window. 00:54:20 - Your body metabolizes xenobiotics differently depending on the time of the day. 00:59:56 - Sauna and exercise improves cardiovascular fitness in a synergistic way. 01:01:28 - Differences between a fasting-mimicking diet vs a water-only fast. 1:03:52 - Balancing protein intake with IGF-1 and mTOR. (01:05:57) 1:11:07 - Prolonged fasting and gallstone risk. (01:13:12) 1:14:40 - Fasting and cardiovascular disease. (01:16:45) 1:15:55 - Comparing two 48-hour fasts vs one 72-hour fast for inducing autophagy and apoptosis. 1:18:40 - Rhonda talks about the benefits of fasting that are independent from ketosis. 1:23:21 - Fasting and cancer 1:25:28 - Time-restricted eating and DNA damage. 1:26:10 - Tips for time-restricted eating for people who work long hours. 1:27:25 - 12-hour vs 10-hour restricted eating windows. 1:27:57 - Time-restricted eating and breastfeeding. 1:28:50 - Diet, lifestyle, and cancer 1:32:32 - Ketosis and Parkinson’s disease. 1:33:29 - Statins, low cholesterol, and Parkinson’s disease. 1:34:01 - Ketogenic diet and blood glucose levels 1:36:50 - Fasting, sauna and muscle mass. 1:42:29 - Eating a carbohydrate rich meal before a workout 1:44:05 - Prolonged fasts and the gut microbiome. 1:51:37 - Contraindications for fasting in women. 1:52:37 - Rhonda’s tips for preventing jet lag in new time zones. 1:54:29 - Rhonda’s tips for managing circadian rhythm in shift-workers. 1:58:04 - The effects of fasting on muscle mass. 2:03:31 - Organs shrink during a fast then regrow during the refeeding phase. 2:08:03 - Supplementing with branch chain amino acids during a fast. 2:09:34 - Tips for refeeding after a prolonged fast. Get more Aliquots! Become a FMF Premium member and get full access to our me
Released:
Feb 25, 2021
Format:
Podcast episode
Titles in the series (25)
PREVIEW Aliquot #16: Time-restricted eating for better metabolic health - Part 1: Time-restricted eating, which involves taking in food within a small window of time during the day and fasting for the remainder, can improve certain biomarkers of health – even without weight loss – to improve overall health. In Part I of this... by The Aliquot Preview