Early studies of omega-3 fatty acid intake demonstrated dramatic biological effects. Since then, the body of research enumerating the profound anti-inflammatory and multi-system, generalized health-promoting qualities of omega-3s continues to grow; however, some studies fail to show any effects from omega-3 supplementation. This source of consternation may, by and large, boil down to low doses, raising the question: what is the right dose of omega-3 to use?  In this Aliquot, Dr. Bill Harris shares his experience administering some of the largest omega-3 doses ever used in human trials and gives his recommendations about optimal dosage taking genes and diet into account. 00:00 - Intro 00:01:51 - Tolerability of very high doses (25 grams or more) 00:14:35 - Why dose titration based on the RBC test is better than ball-parking 00:15:58 - The right dose for 95% of typical Westerner 00:16:30 - Why 4 grams might be better than 2 grams for some people 00:20:00 - How the FDA decided on dosage for prescription omega-3 00:21:05 - Does the omega-6 to omega-3 ratio matter? 00:22:49 - Concluding thoughts Watch the full episode featuring Dr. Bill Harris: https://www.youtube.com/watch?v=-f-CFQxaUY4 FoundMyFitness episode page: https://www.foundmyfitness.com/episodes/bill-harris   Get more Aliquots! Become a FMF Premium member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, biweekly Science Digest emails, and more. Learn more and sign up at: https://www.foundmyfitness.com/aliquot