Happy New Year! And wow, 450 episodes logged! Rounding out 2017, the guys cover listener mail and news before getting to the topic of testosterone replacement therapy for lifters. The mail involves hip replacement expectations and the news delves into muscle metabolism during high-rep sets, as well as what Harvard is saying about scientific evidence in the media. After the mid-show break, the guys offer facts, opinions, and personal observations about hormone replacement therapy in men who need it. From signs and symptoms to expectations, plenty gets discussed! Lastly, sincere Holiday gratitude goes out to Marek, Alan, Robert, Neil, Jennifer, and Andrew for supporting the Iron Brotherhood and Sisterhood so strongly. You are appreciated!