Insulin resistance is when cells stop responding to insulin’s signal to uptake glucose. It’s a hallmark of prediabetes, Type 2 diabetes, and other forms of metabolic dysfunction, and it manifests as several chronic disease, ranging from Alzheimer’s to polycystic ovarian syndrome. Dr. Rob Lustig and Dr. Dominic D’Agostino discuss the importance of monitoring insulin levels, why a high or increasing insulin level is a problem, and how insulin resistance hinders weight management.
? What Rob Lustig, MD, & Dr. Dominic D’Agostino, PhD, discuss:
(03:57) — What is insulin?
(06:55) — What is insulin resistance?
(18:00) — There are three types of insulin resistance
(38:00) — Weight management is not about calories in and calories out
(45:53) — Adding more insulin to the equation of Type 2 diabetes isn’t necessarily the answer
(51:20) — Insulin is a crucial biomarker to measure for metabolic health
(53:58) — Insulin resistance is a hinderance to weight management
(57:07) — The intake of too much leucine can lead to insulin resistance
(1:02:04) — Fiber feeds the gut microbiome and is crucial for metabolic health
(1:13:11) — Is intermittent fasting necessary?
Transcripts & Show notes
Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health.
Look for multiple new shows per week on A Whole New Level, where we have in-depth conversations about metabolic health and how the Levels startup team builds a wellness movement from the ground up in the health and wellness tech industry.

? Helpful links:

Become a Levels member: https://levelshealth.com

Watch the conversation: https://youtu.be/dFOaBrujDHo

Learn about metabolic health: https://levelshealth.com/blog

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Connect with Robert Lustig, MD, on Instagram: https://www.instagram.com/robertlustigmd/

Connect with Robert Lustig, MD, on Twitter: https://twitter.com/RobertLustigMD

Connect with Dominic D’Agostino, PhD, on Instagram: https://www.instagram.com/dominic.dagostino.kt/

Connect with Dominic D’Agostino, PhD on Twitter: https://twitter.com/DominicDAgosti2