I’m a huge proponent of self-experimentation. We can’t always rely on funding for research relevant to our needs, interests, and desires, and those studies that are relevant are still using participants that are not us. We like control, when it comes down to it. We want to be the arbiters of our own destinies, and running (formal or informal) self-experiments of 1 can help us get to that point. But as helpful as it can be, there are both inherent limits to self-experimentation and common pitfalls people fail to take into account when designing their experiments of one.
(This Mark's Daily Apple article was written by Mark Sisson, and is narrated by Brock Armstrong)