Richard Furie, MD, is chief, division of rheumatology, at Northwell Health, and professor of medicine at Hofstra/Northwell School of Medicine. Join us in this ACR interview, as we discuss the story of interferon, lupus therapeutics — including B cell depletion — and the future of lupus research and treatments. Intro :10 Background on Dr. Furie :16 The interview :56 What advancements in the pathophysiology of lupus are you most excited about? 1:10 The interferon story 1:23 The interferon story is not finished yet 7:18 Dendritic cells in lupus patients 7:41 What is “interferon signature?” 8:07 Do we see different clinical phenotype in patients with high interferon signature? 9:38 What’s your opinion on the role of B cells? 10:07 Any other pathophysiology mechanisms being used to target B cells? 13:15 Are we stretched thin in terms of number of lupus patients in trials? 15:21 How would designating lupus as an orphan disease change the way it’s investigated? 16:40 What is your main concern regarding study design? 17:37 Looking 10 years ahead, do you think what we call “lupus” will still be referred to as such, or will it be decompartmentalized into different diseases? 21:26 What’s the expense of cytokine profiling? 22:40 What excites you the most about the future of lupus research? 23:21 Thank you, Dr. Furie 24:41 Recap 24:43 Shout out to the 7th Annual Basic and Clinical Immunology for the Busy Clinician: What is New and Hot in Immunology bootcamp in Scottsdale, AZ, Feb. 15-16, 2019 25:31 We’d love to hear from you! Send your comments/questions to rheuminationspodcast@healio.com. And be sure to follow us on Twitter @AdamJBrownMD and @HealioRheum. This information is brought to you by Healio and is not sponsored by, nor a part of, the American College of Rheumatology.