Leonard Calabrese, DO, details the clinical manifestations of giant cell arteritis, the complex scenarios rheumatologists face when working with GCA, and the pathogenesis of this disease. Calabrese also shares clinical pearls and tips for success.    Introduction of Leonard Calabrese, DO :12 Goals of this episode :31 The disease that rheumatologists love 1:02 History of giant cell arteritis 1:51 Gene Hunder, MD, defines large vessel involvement in late ‘80s, ‘90s 4:18 Epidemiology of giant cell arteritis 4:32 Manifestations in detail 5:13 Cranial arteritis 5:20 Jaw claudication 6:04 Ocular involvement 6:44 Signs and symptoms 7:03 The most important thing about ocular ischemia in GCA 9:01 Stroke: A major complication of cranial ischemic GCA 9:25 PMR and/or systemic inflammatory presentations 11:33 A more recent presentation: inflammatory disease of unknown origin 12:19 Large vessel presentations 13:12 Diagnosis of GCA is based on clinical suspicion 14:00 Ophthalmologists must have hypervigilance 14:22 It’s a team sport to attack this disease 14:58 Overview of clinical manifestations 15:08 Histopathology 16:10 How the biopsy should be done 16:38 What about healed arteritis? 17:18 What about arteritis of the vasa vasorum? 17:41 Episode recap 17:54 The most important thing to know 18:17 Leonard Calabrese, DO, is head of Cleveland Clinic’s Section of Clinical Immunology, co-director of Center for Vasculitis Care and Research, and chief medical editor of Healio Rheumatology. We’d love to hear from you! Send your comments/questions to rheuminationspodcast@healio.com.