This episode delves into the clinical presentation of serum sickness along with a dash of Arthus reaction, to boot! Brought to you by GSK. Intro :10 Today’s episode :26 Let’s get into some cases 4:11 The Arthus reaction 6:06 What is another example of the same thing happening but on a systemic level? 7:25 Breaking down the clinical features of serum sickness 14:20 How confident are we that the compliment levels always drop? 16:26 How common is serum sickness? 19:45 The mechanistics of rituximab 21:36 A preview of parts two and three 27:37 Episode wrap-up 28:38   Disclosures: Brown reports no relevant financial disclosures. We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum References: Bayer G, et al. Eur J Intern Med. 2019;67:59-64. Karmacharya P, et al. Semin Arthritis Rheum. 2015;35-334-340. Lawley TJ, et al. J Invest Dermatol. 1985;85:129s-132s.