This episode covers a rare but life-threatening complication of lupus nephritis called complement-mediated thrombotic microangiopathy. Rheumatologist Lisa Zickuhr, MD, helps us better understand this often-overwhelming topic with a clinical case example, treatment options and practice pearls. Intro :10 Introduction of Lisa Zickuhr, MD, rheumatologist :44 Complement-mediated thrombotic microangiopathy in lupus is an overwhelming topic 1:50 Definition of TMA 2:15 What is MAHA? 3:10 Four classic symptoms associated with TMA syndromes 3:35 What causes TMA? 3:50 Complement-mediated TMA 5:35 How this is seen in clinical practice 9:10 Case example of complement-mediated TMA 10:10 Summary of case presentation 13:05 What’s next? 13:50 Takeaways from this clinical presentation 15:48 Primary and secondary complement-mediated TMA 18:23 An argument for a primary etiology of complement-mediated TMA in lupus 18:51 CliffsNotes version for rheumatologists, HCPs caring for lupus patients 21:12 Therapy for complement-mediated TMA is two-pronged 22:35 Patient profile 24:05 Summary 25:10 Thank you to Dr. Lisa Zickuhr 26:13 Lisa Zickuhr, MD, is a rheumatologist at Washington University in St. Louis. We’d love to hear from you! Send your comments/questions to rheuminationspodcast@healio.com. References: Dragon-Durey MA, et al. J Am Soc Nephrol. 2005:555-563. Dragon-Durey MA, et al. Semin Thromb Hemost. 2010:633-640. George JN, et al. N Engl J Med. 2014 Aug 14;371:654-666. Jönsen A, et al. Arthritis Res Ther. 2011;13:R206. Laszlo MH, et al. Ann Intern Med. 1955;42:1308-1320. Nesher G, et al. Semin Arthritis Rheum. 1994;24:165-72. Zickuhr L, et al. Arthritis Care Res (Hoboken). 2018;doi: 10.1002/acr.23561.