John Stone, MD, MPH, is the world leader in the field of IgG4-related disease research. In this episode, he breaks down the histology of IgG4-related disease, important aspects of what is known about the pathophysiology of the disease, as well as future directions in treatment. Intro :10 Inside this episode :13 IgG4-related disease background :31 An anecdote 1:15 The interview 4:09 History of IgG4-related disease 4:18 IgG4 pathology and terms 7:48 What makes IgG4 different from other IgG subclasses? 10:23 What do we know about the interplay between B and T cells? 12:31 What is SLAMF7? 16:30 What happens to T cells during B-cell depletion? 18:22 Antigens involved in IgG4 21:06 Future of treatment 23:10 Thank you, Dr. Stone 24:32 We’d love to hear from you! Send your comments/questions to rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum John Stone, MD, MPH, is director of clinical rheumatology at Massachusetts General Hospital.