In this podcast, Dr. Wende Gibbs gives us an update on Coronary Artery Calcium Scoring, a valuable tool for early detection and prevention of adverse cardiovascular events, and as a decision-making tool for treatment of patients at risk of cardiovascular disease, including young individuals.  Dr. Ross Frederick summarizes a fascinating multisystem paper which highlights the vital role of radiologists in evaluation of Neurofibromatosis Coronary Artery Calcium Scoring: Current Status and Future Directions. Gupta et al. RadioGraphics 2022; 42:947–967. Neurofibromatosis from Head to Toe: What the Radiologist Needs to Know. Wang et al. RadioGraphics 2022; 42:1123–1144.