Welcome to Episode 1 of CLOT Conversations from Thrombosis Canada. In this episode Dr Jameel Abdulrehman and David Airdrie are joined by Dr Sameer Parpia and Dr Kerstin De Wit,  two of the authors of a recently published paper entitled Diagnosis of deep vein thrombosis with D-dimer adjusted to clinical probability: prospective diagnostic management study. The paper was published in the British Medical Journal (BMJ 2022;376:e067378 https://www.bmj.com/content/376/bmj-2021-067378) earlier this year. The lead investigator was Dr Clive Kearon, who unfortunately passed away in 2020. The study was co-authored by a cross-Canada team of researchers. The authors discuss the study outcomes and their clinical relevance with the hosts in this 20 minute program.Kerstin de Wit trained in internal medicine, emergency medicine and research in the UK. She completed a Thrombosis Fellowship in Ottawa in 2013. Since then, she has worked in both emergency medicine and thrombosis. She leads a research program which focuses on the diagnosis of bleeding and clotting disorders in the emergency department, and is funded by CIHR Sameer Parpia is an Associate Professor in the Departments of Oncology and Health Research Methods, Evidence, and Impact at McMaster University. His interests and expertise are in the design, conduct, monitoring, statistical analysis and reporting of randomized clinical trials. As a senior biostatistician, he provides statistical and methodological leadership for clinical trials in thrombosis. Thrombosis Canada Tools related to the content:Wells Criteria calculator: https://thrombosiscanada.ca/tools/?calc=wellsDVTDVT Diagnosis Algorithm: https://thrombosiscanada.ca/tools/?calc=vivomap263Follow us on Twitter:Thrombosis Canada: @ThrombosisCanDr Sameer Parpia: @ParpiaSameerDr Kerstin De Wit: @kerstindewitSupport the show