In this episode Dr Jameel Abdulrehman and David Airdrie are joined by Dr Yan Xu, one of the authors of a recently published review paper entitled Evaluation of definitions for oral anticoagulant-associated major bleeding: A population-based cohort study, co-authored by Yan Xu, Tara Gomes, Philip S. Wells, Priscila Pequeno, Ana Johnson, and Michelle Sholzberg. The paper was published in Thrombosis Research (Thrombosis Research 213 (2022) 57–64) available here: https://www.thrombosisresearch.com/article/S0049-3848(22)00055-X/fulltextDr Xu provides an overview of how the ISTH, BARC, and TIMI definitions for major bleeding on anticoagulation differ and the impact that has on research outcomes. His review explores the study results and what they may mean for future studies.Biography:Dr. Yan Xu, is a subspecialty fellow in Adult Thrombosis Medicine at the University of Ottawa, having completed his medical school at Queen’s University, internal medicine training at the University of Toronto and hematology fellowship at The Ottawa Hospital. Yan’s research interests involve the use of routine clinical data to better understand the safety of anticoagulant therapy, and how to optimally manage bleeding complications that arise from their use. His work has been supported by the Canadian Institutes of Health Research, the American Society of Hematology, and the CanVECTOR Network.Thrombosis Canada Tools related to the content:Bleed management algorithm: https://thrombosiscanada.ca/tools/?calc=vivomap271Clinical Guide: DOACs, Management of Bleeding: https://thrombosiscanada.ca/wp-uploads/uploads/2021/11/23.-DOACs-Management-Bleeding_29November2021-1.pdfFollow us on Twitter:Thrombosis Canada: @ThrombosisCanDr Yan Xu: @IMYanXuReference:  Yan Xu, Tara Gomes, Philip S. Wells, Priscila Pequeno, Ana Johnson, Michelle Sholzberg, Evaluation of definitions for oral anticoagulant-associated major bleeding: A population-based cohort study, Thrombosis Research, Volume 213, 2022, Pages 57-64.Support the show