This episode is one of our Premium-exclusive AMA (ask me anything) episodes, where we answer questions submitted by Premium subscribers. To listen to the full 90 minute episode, you’ll need to be a Premium subscriber and access the episode on the private Premium feed. Otherwise, you can hear a preview of the episode here. Full List of Questions: [01:50] How should one interpret the systematic reviews done by Hooper et al that report no association between modification or reduction of saturated fat intake with cardiovascular mortality, total mortality, non-fatal MI? [22.10] Given most people don’t meet them, are public health targets for fruit and vegetables too high? [29.10] What is the role of homocysteine in heart disese? Is it causal? [40:45] Monounsaturated Fat: Good, Bad or Indifferent? [50:13] Is there evidence to suggest an upper limit for BMI, where even individuals with a ‘healthy’ body composition would be at elevated risk? [59:32] Where does the current research stand on the impact of diet on brain health? [01:08:48] Based on recent findings, do we have to throw out previous research on diet’s impact on the gut microbiome?