This episode is brought to you by Rupa Health and Paleovalley.Contrary to popular belief, holding on to weight isn’t just about a lack of willpower or not exercising enough; even genetics plays just a minor role. There are numerous other factors that influence our weight, including things like our gut microbiome, toxins, mitochondrial function, hormones, and even our social networks. But by applying the principles of Functional Medicine, we can peel back the layers to determine where the focus needs to be for each individual to support and balance their body and help them achieve a healthy weight.In this episode of my Masterclass series, I am interviewed by my good friend and podcast host, Dhru Purohit, about the eight reasons we can’t lose weight and how to overcome roadblocks in weight loss.Dhru Purohit is a podcast host, serial entrepreneur, and investor in the health and wellness industry. His podcast, The Dhru Purohit Podcast, is a top 50 global health podcast with over 30 million unique downloads. His interviews focus on the inner workings of the brain and the body and feature the brightest minds in wellness, medicine, and mindset.This episode is brought to you by Rupa Health and Paleovalley. Rupa Health is a place where Functional Medicine practitioners can access more than 2,000 specialty lab tests from over 20 labs like DUTCH, Vibrant America, Genova, and Great Plains. You can check out a free, live demo with a Q&A or create an account at RupaHealth.com. Paleovalley is offering my listeners 15% off their entire first order. Just go to paleovalley.com/hyman to check out all their clean Paleo products and take advantage of this deal.In this episode, we discuss (audio version / Apple Subscriber version):Eight reasons you are holding on to weight (4:36 / 1:00) Being overfed and undernourished (7:44 / 4:21)The role of the gut microbiome (10:03 / 6:32)  Inflammation and immune function (13:12 / 9:48) How toxins impact weight (14:44 / 11:20) The importance of energy production (16:51 / 13:30) The communication system, including hormones (18:43 / 15:23) Genes attributed to obesity (24:28 / 20:57) The value of a health-oriented social network (28:43 / 25:16) Questions from our community (33:34 / 29:44) Mentioned in this episode:The UltraThyroid Solution PDFWeight Loss PDFLevelsIn the Realm of Hungry Ghosts by Dr. Gabor MateByron Katie “The Work” Byron Katie Video See acast.com/privacy for privacy and opt-out information.