00:52 – Introducing today’s guest, David Sinclair06:28 – David’s origin story08:38 – Why we age11:17 – The genome and epigenome13:00 – The piano metaphor15:51 – Sirtuins explained21:59 – Other environmental stressors that sirtuins detect25:11 – Hormesis defined28:13 – How NAD+ and its precursors combat aging35:11 – Dr. Stephanie brings up a specific story from Dr. David’s book38:40 – Friedreich's Ataxia39:27 – Benefits of resveratrol45:11 – Horvath's Clock and measuring age accurately47:58 – The backup copy of the epigenome53:44 – Anti-aging technologies on the horizon55:07 – Other anti-aging best practices56:47 – Dr. Stephanie suggests a new sequel to the Avengers franchise57:48 – Dr. Stephanie thanks Dr. David for joining the show58:21 – Dr. David shares with the audience where they can find the cheat sheet in his book58:48 – Where listeners can follow Dr. David1:00:00 – Where listeners can follow Dr. Stephanie and subscribe to her newsletterTWEETABLE QUOTES“I wrote the book because there’s a lot of really interesting technology and things people can do in their daily lives, I believe, to live significantly longer and healthier. But, I also wanted to start the conversation because I felt no one was really saying the kinds of things that I was saying.” (08:15)“I think that the major driver of aging, put simply, is a loss of information.” (10:19)“I think it’s worth clarifying that the sirtuins are protectors of our bodies, but they can also cause aging by being distracted too much.” (25:11)“It’s all about being uncomfortable. Our bodies would much rather sit in a chair and eat popcorn. There’s a whole industry based on that.” (26:19)“I like to joke that scientists like to fight because the stakes are so low.” (42:41)“We can predict, very accurately, how old someone is biologically. And that’s not so much related to birthday candles. It’s more about how you’ve lived your life. Twenty percent of your age will be genetic and eighty percent will be how you’ve lived.” (46:59)“What I don’t know is how to bring people back from the dead, but I think we’re getting close to being able to keep people alive in a healthy way for much longer.” (57:31)LINKS MENTIONEDBetter! WebsiteDr. Stephanie’s WebsiteDr. Stephanie’s Twitter – @dr_stephanieDr. Stephanie’s Instagram – @dr.stephanie.estimaDr. Stephanie on LinkedInDr. David’s Book - Lifespan: Why We Age―and Why We Don't Have ToDr. David’s WebsiteDr. David’s Instagram – @davidsinclairphdDr. David’s Twitter – @davidasinclairDr. David’s FacebookADDITIONAL RESOURCES FOR THIS PODCASTIn animal models, more NAD is betterAt least when it is paired with exerciseThe Mathematical Theory Of AgingThe Horvath ClockReversal Of Aging & Cellular ReprogrammingResveratrol effects 1 Resveratrol effects 2NMN & lifespan in miceDavid’s NewsletterDavid’s bookENJOYING THE SHOW, READY FOR MORE?Please Subscribe to Better! With Dr. StephanieJoin our Private Facebook Community for Better!Rate and Review: Show your support and help spread the word by writing a review, along with a 5-star rating on Apple Podcasts: https://bettershow.co/apple?️?️?️Podcast production and marketing provided by FullCast