David Andrew Sinclair, PhD is an Australian biologist who is a professor of genetics and co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School. He is known for his research on aging with a focus on epigenetics. Time Stamps:0:35:27 Podcast begins with David Sinclair0:36:25 Is when we eat more important than what we eat?0:38:45 What is the connection between time restrictive eating and longevity?0:43:54 What causes us to age?0:45:46 Epigenetic change.0:52:03 What causes DNA breaks?0:55:28 What plant foods create DNA breaks?0:57:13 PARP enzymes 1:00:46 Where does NAD come from? How do we make it? What enzymes use it?1:04:50 NAD recycling pathway.1:12:13 Sirtuins.1:24:14 What are the other longevity genes? (AMP kinase and mTOR) How are they connected to sirtuins?1:31:50 Does being in a ketogenic state increase NAD?1:40:30 Xenohormesis and plant molecules.1:45:50 Resveratrol trials.1:51:55 mTOR.1:57:25 David’s thoughts on animal protein.2:04:03 Meat consumption in relation to the environment and regenerative agriculture.2:11:28 Where to find David Sinclair. David’s info:https://genetics.med.harvard.edu/sinc... https://lifespanbook.com/Instagram: @davidsinclairphdTwitter: @davidasinclair Sponsors: Heart & Soil: www.heartandsoil.co White Oak Pastures: www.Whiteoakpastures.com, use code: CarnivoreMD for 10% off your first order The Cold Plunge: TheColdPlunge.com, use code CarnivoreMD for $111 off your cold plunge Eight Sleep: https://www.eightsleep.com/carnivoremd use code “CARNIVOREMD” to save $150 Sacred Hunting: www.sacredhunting.com/Paul for $250 off your hunt