Multi-omics is the layering of genetic information (genomics) with laboratory biomarker results (metabolomics) to understand the root cause of disease and risk. This educational series focuses on genetic variants in specific enzymes and explains how to evaluate the systemic effects.
Today’s episode revolves around the enzyme cystathionine-beta-synthase (CBS). This enzyme is important for homocysteine metabolism, sitting at a branch point between two important cycles: methylation and transsulfuration. The action of this enzyme is important for balancing the critical functions of methylation with the creation of glutathione and energy. Listen to understand why this enzyme is important and what a genetic variant in CBS might mean for your patients.
“You’ve got to zoom out. You’ve got to look at all of the factors which regulate the CBS enzyme.” – Michael Chapman, ND
 
Today on The Lab Report:

2:20 Reminder of what we mean by multi-omics
4:50 Introducing the CBS enzyme and the sink drain metaphor
7:40 The genetics of CBS – the silent mutation – and its potential effects
12:40 Better Know A Biomarker:  Cystathionine!
16:20 Activators and inhibitors of CBS and its effects on other biomarkers
18:55 Question of the Day:  Does a CBS SNP cause elevated ammonia levels?
21:40 Evaluating surrounding biomarkers and how do you treat this SNP?

 
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Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.See omnystudio.com/listener for privacy information.