Dr Glenn McConell chats with Professor Laurie Goodyear from the Joslin Diabetes Centre at Harvard Medical School. Laurie is a very big name in the field of exercise metabolism with a remarkable track record. She has examined glucose and fat metabolism during exercise and more recently has been focusing on developmental origins of health and disease and the benefits of exercise. Exercise of the mother, the father and even the grandmother has beneficial effects on offspring, especially if the parents were on a high fat diet. The role of epigenetics is discussed.  
0:00. Introduction 
3:20. How Laurie ended up in exercise research. Started off very applied and then mechanistic.
8:02. Developmental origins of health and disease. Dutch famine etc. 
12:22. Rodents allow observations over a lifetime.
13:00. Genetics and epigenetics 
17:30. What you do during your life affects what’s passed on 
18:30. Maternal exercise and offspring health. High fat diets with and without exercise 
25:50. Effects on the placenta /liver SOD3 activates AMPK. Need normal Vitamin D and exercise
28:20. Human studies appear to fit with the rodent findings 
33:00. Paternal exercise and offspring health High fat diets with and without exercise 
37:40. Grand-maternal exercise 
40:29. Voluntary wheel running 
42:08. Recommendations before conceive 
44:00. Translation of mice running wheel results to humans. Normally active is the control. Sedentary behaviour is the treatment. 
49:36. Real life: Things not working in the lab 
52:34. How much the high fat diet vs obesity? 
54:38. Exercise early in life can overcome issues. Pancreas.
58:10. Organ cross talk. Fat cells and exercise. Adipokines. Lactate signaling the adipose tissue. 
1:01:03. Take away messages.
Inside Exercise brings to you the who's who of exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.  
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.  
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).  
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