Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt  Plenty more at https://chrismasterjohnphd.com/support! Question: Can a high-protein diet hurt nitric oxide and raise blood pressure? The people with OTC gene do have higher blood pressure because of lower nitric oxide. And they have a problem eating too much protein, but the protein is a problem, because they can exceed the capacity of the urea cycle and generate more ammonia. Whereas the OTC gene being low is what's driving the low nitric oxide to lower arginine production. So you are seeing the combination of this person should not eat too much protein. This person has low nitric oxide, high blood pressure, but I don't think it's the protein that's causing that. I think it's just low arginine synthesis due to low citrulline synthesis. And so they should supplement citrulline to improve their blood pressure. And they probably shouldn't eat too much protein, but I don't think that too much protein is going to be the thing that drives the high blood pressure. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.