Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt  Plenty more at https://chrismasterjohnphd.com/support! Question: Combining carbs and fat, LDL-C, calcification, and atherosclerosis Generally speaking, if someone is overweight and hyperglycemic, then they're probably going to get a lot of benefit from trying to separate their carbs and fat, whereas if someone has amazing body composition and a totally healthy blood glucose level while they're eating a mixed diet, then I think it's kind of pointless. I would say that for blood lipids, generally, if macronutrients are going to affect your blood lipids, that's probably involving your fasting blood lipids, which is what's usually measured. If changing your macronutrients around is going to affect those, I think it's probably going to be in the context of some level of insulin resistance or overweightness, really insulin resistance or it would just be one of several ways to get there with carbohydrates generally pumping the sort of VLDL production and triglyceride content. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.