A Simple Guide to Mucocutaneous Lymph Node Syndrome (Kawasaki Disease), Diagnosis, Treatment and Related Conditions

By Kenneth Kee

This book describes Mucocutaneous Lymph Node Syndrome (Kawasaki Disease), Diagnosis and Treatment and Related Diseases

Mucocutaneous lymph node syndrome is a childhood disease
The disease occur in children of all ages
It typically cause fever and lymph node swellings
Mostly it causes the skin to start peeling.

Patients present with first with fever then skin and eye dryness
There may be also swelling of feet and hand with redness
There is also sore throat with sometimes tonsillar swelling
This is followed by red rash with skin peeling

Diagnosis is by symptoms and elimination of other diseases
Electrocardiography may be done to check on heart myopathy
Complications are vasculitis, coronary heart disease and arthritis
There may be also blood vessel aneurysm and myocarditis

Treatment is usually with immunogammaglobulin
Aspirin is also used under proper doctor’s supervision
Corticosteroids is useful to treat arthritis and myocarditis
Most children make a full recovery after about 3 weeks

-An original poem by Kenneth Kee

Mucocutaneous lymph node syndrome, also known as Kawasaki disease, is a rare condition that primarily affects young children and typically causes fever, swelling of the lymph nodes, and symptoms affecting the skin and mucous membranes.

Mucocutaneous lymph node syndrome is a more suitable name for this because of its symptoms affecting the skin and mucous membranes and lymph node enlargement than Kawasaki disease.

It is characterized by inflammation of the blood vessels throughout the body, including the coronary arteries, and can lead to complications such as aneurysms or heart disease.

Mucocutaneous lymph node syndrome happens mainly in children below 5 years.

It does not transmit from child to child (is not contagious).

The disorder happens most often during the periods of late winter and early spring.

Mucocutaneous lymph node syndrome can harm the coronary arteries which carry blood to the heart muscle.

Most of the treated children can recover from the disease without long-term disorders.

The precise cause is not known, but it is thought to be linked to a wind-borne or water-borne pathogen infection.

An autoimmune disease has been proposed as the cause.

In recent years there have been studies that have revealed certain genetic markers (such as HLA-B51 and HLA-Bw22j2 serotypes, chemokine receptor gene-cluster CCR2-CCR5 haplotypes and FCGR3A polymorphism of the IgG receptor IIIa) demonstrate a predisposition to the disease.

The siblings of patients are 10-20 times likely to develop the disease compared to normal people.

The triad of symptoms which are frequent are:
Fever together with headache persisting for more than 5 days
Swelling of one or more lymph nodes in the neck
Blotchy red rash over the entire body with typical skin peeling in the second week of illness

The diagnosis is always clinical.

Classical symptoms and signs are 5 days of high fever, lymph nodes enlargement, rash and peeling of the skin from the fingers and toes.

Echocardiography is the investigation of choice to assess for coronary artery aneurysms.

The standard treatment during the disorder's acute stage is high-dose aspirin and immune globulin.

Most children who receive these treatments improve rapidly within 24 hours.

For a small percentage of patients, the fever persists.

These children may necessitate a second round of intravenous immunoglobulin.

There are new clinical trials with the use of infliximab, etanercept, and anakinra.

TABLE OF CONTENT
Introduction
Chapter 1 Mucocutaneous Lymph Node Syndrome
Chapter 2 Causes
Chapter 3 Symptoms
Chapter 4 Diagnosis
Chapter 5 Treatment
Chapter 6 Prognosis
Chapter 7 Scarlet fever
Chapter 8 Infectious Mononucleosis
Epilogue

• Language: English
• Publisher: Kenneth Kee
• Release date: Feb 25, 2023
• ISBN: 9798215590225

Kenneth Kee

Medical doctor since 1972.Started Kee Clinic in 1974 at 15 Holland Dr #03-102, relocated to 36 Holland Dr #01-10 in 2009.Did my M.Sc (Health Management ) in 1991 and Ph.D (Healthcare Administration) in 1993.Dr Kenneth Kee is still working as a family doctor at the age of 74However he has reduced his consultation hours to 3 hours in the morning and 2 hours inthe afternoon.He first started writing free blogs on medical disorders seen in the clinic in 2007 on http://kennethkee.blogspot.com.His purpose in writing these simple guides was for the health education of his patients which is also his dissertation for his Ph.D (Healthcare Administration). He then wrote an autobiography account of his journey as a medical student to family doctor on his other blog http://afamilydoctorstale.blogspot.comThis autobiography account “A Family Doctor’s Tale” was combined with his early “A Simple Guide to Medical Disorders” into a new Wordpress Blog “A Family Doctor’s Tale” on http://ken-med.com.From which many free articles from the blog was taken and put together into 1000 eBooks.He apologized for typos and spelling mistakes in his earlier books.He will endeavor to improve the writing in futures.Some people have complained that the simple guides are too simple.For their information they are made simple in order to educate the patients.The later books go into more details of medical disorders.He has published 1000 eBooks on various subjects on health, 1 autobiography of his medical journey, another on the autobiography of a Cancer survivor, 2 children stories and one how to study for his nephew and grand-daughter.The purpose of these simple guides is to educate patient on health disorders and not meant as textbooks.He does not do any night duty since 2000 ever since Dr Tan had his second stroke.His clinic is now relocated to the Buona Vista Community Centre.The 2 units of his original clinic are being demolished to make way for a new Shopping Mall.He is now doing some blogging and internet surfing (bulletin boards since the 1980's) startingwith the Apple computer and going to PC.The entire PC is upgraded by himself from XT to the present Pentium duo core.The present Intel i7 CPU is out of reach at the moment because the CPU is still expensive.He is also into DIY changing his own toilet cistern and other electric appliance.His hunger for knowledge has not abated and he is a lifelong learner.The children have all grown up and there are 2 grandchildren who are even more technically advanced than the grandfather where mobile phones are concerned.This book is taken from some of the many articles in his blog (now with 740 posts) A Family Doctor’s Tale.Dr Kee is the author of:"A Family Doctor's Tale""Life Lessons Learned From The Study And Practice Of Medicine""Case Notes From A Family Doctor"

Book preview

A

Simple

Guide

To

Mucocutaneous Lymph Node Syndrome

(Kawasaki Disease),

Diagnosis,

Treatment

And

Related Conditions

By

Dr Kenneth Kee

M.B.,B.S. (Singapore)

Ph.D (Healthcare Administration)

Copyright Kenneth Kee 2023 Smashwords Edition

Published by Kenneth Kee at Smashwords.com

Dedication

This book is dedicated

To my wife Dorothy

And my children

Carolyn, Grace

And Kelvin

This book describes Mucocutaneous Lymph Node Syndrome (Kawasaki Disease), Diagnosis and Treatment and Related Diseases which is seen in some of my patients in my Family Clinic.

(What You Need to Treat Mucocutaneous Lymph Node Syndrome)

This e-Book is licensed for your personal enjoyment only. This eBook may not be re-sold or given away to other people. If you would like to share this book with another person, please purchase an additional copy for each reader.

If you’re reading this book and did not purchase it, or it was not purchased for your use only, then please return to Smashwords.com and purchase your own copy.

Thank you for respecting the hard work of this author.

Introduction

I have been writing medical articles for my blog: http://kennethkee.blogspot.com (A Simple Guide to Medical Disorder) for the benefit of my patients since 2007.

My purpose in writing these simple guides was for the health education of my patients.

Health Education was also my dissertation for my Ph.D (Healthcare Administration).

I then wrote an autobiography account of my journey as a medical student to family doctor on my other blog: http://afamilydoctorstale.blogspot.com.

This autobiography account A Family Doctor’s Tale was combined with my early A Simple Guide to Medical Disorders into a new Wordpress Blog A Family Doctor’s Tale on http://kenkee481.wordpress.com.

From which many free articles from the blog was taken and put together into 800 eBooks.

Some people have complained that the simple guides are too simple.

For their information they are made simple in order to educate the patients.

The later books go into more details of medical disorders.

The first chapter is always from my earlier blogs which unfortunately tends to have typos and spelling mistakes.

Since 2013, I have tried to improve my spelling and writing.

As I tried to bring the patient the latest information about a disorder or illness by reading the latest journals both online and offline, I find that I am learning more and improving on my own medical knowledge in diagnosis and treatment for my patients.

My diagnosis and treatment capability has improved tremendously from my continued education.

Just by writing all these simple guides I find that I have learned a lot from your reviews (good or bad), criticism and advice.

I am sorry for the repetitions in these simple guides as the second chapters onwards have new information as compared to my first chapter taken from my blog.

I also find repetition definitely help me and maybe some readers to remember the facts in the books more easily.

I apologize if these repetitions are irritating to some readers.

Chapter 1

Mucocutaneous lymph node syndrome (Kawasaki disease)

Mucocutaneous lymph node syndrome is a childhood disease

The disease occur in children of all ages

It typically cause fever and lymph node swellings

Mostly it causes the skin to start peeling.

Patients present with first with fever then skin and eye dryness

There may be also swelling of feet and hand with redness

There is also sore throat with sometimes tonsillar swelling

This is followed by red rash with skin peeling

Diagnosis is by symptoms and elimination of other diseases

Electrocardiography may be done to check on heart myopathy

Complications are vasculitis, coronary heart disease and arthritis

There may be also blood vessel aneurysm and myocarditis

Treatment is usually with immunogammaglobulin

Aspirin is also used under proper doctor’s supervision

Corticosteroids is useful to treat arthritis and myocarditis

Most children make a full recovery after about 3 weeks

-An original poem by Kenneth Kee

What is Mucocutaneous lymph node syndrome?

Mucocutaneous lymph node syndrome, also known as Kawasaki disease, is a rare condition that primarily affects young children and typically causes fever, swelling of the lymph nodes, and symptoms affecting the skin and mucous membranes.

Mucocutaneous lymph node syndrome is a more suitable name than Kawasaki disease because of its symptoms affecting the skin and mucous membranes and lymph node enlargement.

It is characterized by inflammation of the blood vessels throughout the body, including the coronary arteries, and can lead to complications such as aneurysms or heart disease.

3000 children with Mucocutaneous lymph node syndrome are hospitalized yearly in the USA.

Mucocutaneous lymph node syndrome is a rare childhood illness that harms the blood vessels to the heart.

Mucocutaneous lymph node syndrome happens mainly in children below 5 years.

It is most frequent in children ages 1 to 2 years and less common in children older than age 8.

It does not transmit from child to child (is not contagious).

The disorder happens most often during the periods of late winter and early spring.

Symptoms can involve a fever, rash, swollen lymph nodes, red eyes, and swollen hands and feet.

These symptoms can be serious for several days and can appear frightening to parents.

The majority of these affected children can return to normal activities.

One notable feature other than high fever and skin peeling is the effect of the disease on the arterial system of the heart.

Mucocutaneous lymph node syndrome can harm the coronary arteries which carry blood to the heart muscle.

Most of the treated children can recover from the disease without long-term disorders.

What is the cause of Mucocutaneous lymph node syndrome?

Cause

The precise cause of Mucocutaneous lymph node syndrome is not known, but it is thought to be linked to a wind-borne or water-borne pathogen infection.

An autoimmune disease has been proposed as the cause of the Mucocutaneous lymph node syndrome.

In recent years there have been studies that have revealed certain genetic markers (such as HLA-B51 and HLA-Bw22j2 serotypes, chemokine receptor gene-cluster CCR2-CCR5 haplotypes and FCGR3A polymorphism of the IgG