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    Scleroderma, A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions
    Scleroderma, A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions
    Scleroderma, A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions
    Ebook150 pages1 hour

    Scleroderma, A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions

    By Kenneth Kee

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    About this ebook

    This book describes Scleroderma, Diagnosis and Treatment and Related Diseases
    Scleroderma is an autoimmune disease typically featured by the poor regulation of the immune system, vasculopathy and fibrosis.
    It is a connective tissue disorder featured primarily by the thickening and hardening of the skin produced by accumulation of collagen, and by injuries to the smallest arteries.
    There are 2 main types of scleroderma: localized and systemic.
    In localized scleroderma, the disease involves mainly the skin and may have an effect on the muscles and bones.
    In systemic scleroderma, there is a participation of the internal organs, such as the digestive tract, heart, lungs, and kidneys, among others.
    The severity and prognosis of scleroderma are inconsistent.
    There are 2 subtypes of Scleroderma:
    1. Limited cutaneous Systemic Sclerosis (LcSSc)
    In LcSSc the skin thickening and hardening happens in the fingers, hands, face, forearms distal to elbow, and lower legs distal to the knees.
    LcSSc is linked with anti-centomere antibodies, pulmonary arterial hypertension (PAH) with or without interstitial lung disease (ILD).
    CREST syndrome (Calcinosis, Raynaud's phenomenon, Esophageal dysfunction, Sclerodactyly, Telangiectasias) is linked with LcSSc.
    2. Diffuse cutaneous Systemic Sclerosis (DcSSc)
    In DcSSc the skin thickening and hardening happens proximal to the elbows and knees and may affect the trunk.
    DcSSc normally have a faster start and progression and is at danger of progressing to the visceral organs, such as the kidneys, heart, lungs and gastrointestinal tract.
    Normal involvements are:
    a. Interstitial lung disease with or without PAH, cardiomyopathy,
    b. Diffuse gastrointestinal disease and
    c. Renal crisis.
    Cause
    The precise cause of scleroderma is not fully known.
    There is some presence that genetic and environmental factors have a part in the genesis of scleroderma.
    Silica and certain organic solvents are documented as danger factors.
    The result is a trigger of the immune system, causing blood vessel injury and damage to tissues that cause scar tissue formation and the collection of excess collagen.
    Genetic factors have at least a limited part.
    Symptoms
    Scleroderma produces thick, hard patches of skin.
    Localized scleroderma is restricted to the skin and underlying tissue
    Systemic Sclerosis
    Systemic Sclerosis you are so scary
    Your disease attacked my whole body
    Most of all my skin is tight and thickened
    My fingers are all puffy and swollen.
    My skin is so itchy and sometimes painful
    My fingers becomes blue when it becomes cool
    A condition called Raynauld's phenomenon
    There is distension always in my abdomen
    Sometimes I have heartburn and problem swallowing
    I feel as though my intestinal tract is not moving
    Sometime my body is unable to absorb any nutrition
    And I end up with either diarrhea or constipation
    I tend to get overgrowth of bacteria in my GIT
    I even soil my underwear before I could pass it
    My heart enlarges and I develop pulmonary arterial hypertension
    Is that why I am so breathless or is it due to lung infection
    Doctor please be kind, keep me warm
    And give medicine to keep me strong
    Do not let my kidney fail or falter
    Let me spend some time with my son and daughter
    -An original poem by Kenneth Kee

    Diagnosis:
    1. Physical signs of skin thickening, puffy fingers
    2. Auto antibodies-antinuclear antibody test is positive in majority of cases (90%)
    3. Nail capillaroscopy is a method to study micro circulation of nail bed
    Treatment
    There is no cure for Scleroderma
    Topical corticosteroids are the primary treatment.
    Stem cell transplantation and treatments directing on cytokine signaling, such as interleukin-6 (IL-6), have produced promising results

    TABLE OF CONTENT
    Introduction
    Chapter 1 Scle

    LanguageEnglish
    PublisherKenneth Kee
    Release dateOct 17, 2019
    ISBN9780463645802
    Scleroderma, A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions
    Author

    Kenneth Kee

    Medical doctor since 1972.Started Kee Clinic in 1974 at 15 Holland Dr #03-102, relocated to 36 Holland Dr #01-10 in 2009.Did my M.Sc (Health Management ) in 1991 and Ph.D (Healthcare Administration) in 1993.Dr Kenneth Kee is still working as a family doctor at the age of 74However he has reduced his consultation hours to 3 hours in the morning and 2 hours inthe afternoon.He first started writing free blogs on medical disorders seen in the clinic in 2007 on http://kennethkee.blogspot.com.His purpose in writing these simple guides was for the health education of his patients which is also his dissertation for his Ph.D (Healthcare Administration). He then wrote an autobiography account of his journey as a medical student to family doctor on his other blog http://afamilydoctorstale.blogspot.comThis autobiography account “A Family Doctor’s Tale” was combined with his early “A Simple Guide to Medical Disorders” into a new Wordpress Blog “A Family Doctor’s Tale” on http://ken-med.com.From which many free articles from the blog was taken and put together into 1000 eBooks.He apologized for typos and spelling mistakes in his earlier books.He will endeavor to improve the writing in futures.Some people have complained that the simple guides are too simple.For their information they are made simple in order to educate the patients.The later books go into more details of medical disorders.He has published 1000 eBooks on various subjects on health, 1 autobiography of his medical journey, another on the autobiography of a Cancer survivor, 2 children stories and one how to study for his nephew and grand-daughter.The purpose of these simple guides is to educate patient on health disorders and not meant as textbooks.He does not do any night duty since 2000 ever since Dr Tan had his second stroke.His clinic is now relocated to the Buona Vista Community Centre.The 2 units of his original clinic are being demolished to make way for a new Shopping Mall.He is now doing some blogging and internet surfing (bulletin boards since the 1980's) startingwith the Apple computer and going to PC.The entire PC is upgraded by himself from XT to the present Pentium duo core.The present Intel i7 CPU is out of reach at the moment because the CPU is still expensive.He is also into DIY changing his own toilet cistern and other electric appliance.His hunger for knowledge has not abated and he is a lifelong learner.The children have all grown up and there are 2 grandchildren who are even more technically advanced than the grandfather where mobile phones are concerned.This book is taken from some of the many articles in his blog (now with 740 posts) A Family Doctor’s Tale.Dr Kee is the author of:"A Family Doctor's Tale""Life Lessons Learned From The Study And Practice Of Medicine""Case Notes From A Family Doctor"

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      Scleroderma, A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions - Kenneth Kee

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