The 5 balances of health

By Marcos Mazzuka

The 5 Balances of Health gives the answer to the questions on how and why diseases occur, and how to anticipate them, avoid them and treat them.
Dr. Marcos Mazzuka exposes his experiences made in almost forty years dedicated to the research and treatment of various diseases such as fibromyalgia, cancer, depression and autoimmune diseases, all of them analyzed in the light of scientific investigations carried out in the last few years.
Cellular Regenerative Medicine emerges with strength, supported by evidence-based biochemical knowledges, in order to give a solution that can be applied by everybody, in their daily lives, managing to retrieve their balances and lost health.

• Language: English
• Publisher: Editorial Bubok Publishing
• Release date: Sep 23, 2016
• ISBN: 9788468692524

Book preview

The 5 Balances of Health

cancer, autoimmune diseases,

chronic fatigue, psychological imbalances

how to prevent and treat them

Dr. Marcos Mazzuka P.

Phd. Cell Regenerative Medicine

© Marcos Mauzzka

© The 5 Balances of Health

Translated by Johnny Lazzaro.

Proofreading: Johnny Lazzaro & Monika Wagner

([e-mail])

ISBN papel: 978-84-686-9243-2

ISBN digital: 978-84-686-9252-4

Depósito legal: M-33718-2016

Editor Bubok Publishing S.L.

Impreso en España/Printed in Spain.

All rights reserved. Total or partial reproduction of this work, or incorporation into a computer system, or transmission in any form or by any means (electronic, mechanical, photocopying, recording or otherwise) is not permitted without prior authorization. The infringement of such rights may constitute an offense against intellectual property.

Introduction

«Today’s truth is tomorrow’s lie»

I must consider that this aphorism has been the leitmotif throughout my professional life.

I can remember the day I heard it for the first time: it was from the mouth of our mentor over 30 years ago,

And to tell the truth, at that time, either due to the excitement for having achieved my Specialist in Pediatrics Degree, after grueling endless guard service or because

I was discussing with my neighboring colleague on a case that we had seen in the last review, I must say that I did not understand what it really meant.

At first, I thought that it had been a kind of joke the master wanted to play us, as if pointing out that all that we had learned with so much effort was worth nothing, which seemed to be what my colleagues had caught, judging by the laughter that flooded the sala magna of the University.

But it was long after when, over the years, through in-

depth studies into my specialty, and opening myself to other medical fields, I could understand the meaning of those words: «Despite everything you have learned, if you don’t keep up to date, your knowledge, that is your truth, will disappear». I felt like being born again and that made me understand that not only do we have to keep updated because knowledge advances and, occasionally, it may even contradict itself, but also, there is not only one inescapable and irrefutable truth. There are many truths and all of them are important. As a network of threads, each thread constitutes one truth that has the same value as the others, because if you touch it, the whole will be affected.

I have never discarded a piece of information, a concept or a point of view. Everything is valid within the critical mind. We have the capacity of discerning, by using the filter of our intelligence, that is based on lessons learned and on the solidity of our experiences. For this reason, l never discard a concept, however strange it may seem, I try to integrate it within that network that we call life.

If I cannot fit it, I put it in a position of study for the future generations to finally do it, in the light of new knowledges.

By this book I do not intend to tell the Truth, I only intend to expose those ones I found in the field of health and aging and which have the value of the observations throughout my professional life, because the truth is shaped by the experiences and the knowledge acquired by each of us and we use it as a prism to view life under our personal viewpoint.

Therefore, what you are going to read here may be refuted, denied, shared or accepted, and all choices will be valid, because each of us is entitled to find his own truths.

Dr. Marcos Mazzuka Petitta

PART ONE

I

What is cell regenerative medicine?

Before the second world war there was a character whose knowledge embraced all that we consider today to be the medicine : the doctor. With his briefcase and a few instruments he managed to accomplish what French doctors Bérard and Gubler claimed since the 19th century: «To cure sometimes, to relieve often, to comfort always».This character had a broad view of the patient’s condition because he became part of the family. Therefore he knew his way of life, customs and vices, and within his scientific knowledge of the time he could give a diagnosis, and consequently, a treatment.

However, the interesting thing was the dismemberment of that physical-emotional-spiritual entity called human being into pieces, and the name of these pieces gave rise to what is known today as the «medical specialties».

Maybe at the beginning the idea was laudable: the scientific knowledge, based on the study of matter, what is visible, palpable, was increasingly huge and almost impossible to be retained by the limited brain of a single man. For this reason it was decided to investigate every single apparatus, organs and systems as if they were a machine spare parts in order to, in a joint review, give a later diagnosis much more accurate and effective for therapeutic purposes. According to my point of view, two big mistakes were committed: one initial, conceptual error, followed by an error of praxis.

The first to which I am referring is that, a priori, by the mere fact that when something is not tangible or measurable it is completely discarded: that is, the spiritual element.

But this is perhaps understandable, because it used to be a medicine which had focused for the past two centuries on the study of matter, having no instruments to measure what Aristotle recognized as the center of our «being», the soul; in addition to being somewhat uncomfortable for a science which rules out any possibility of intervention from things that are not understood or accepted.

Better luck there was for the other human element, emotion, under the influence of great thinkers-observers as were Sigmund Freud and Carl Gustav Jung, who provided the basic concepts, but not all of them accepted, on the role of the human psyche. This lays the foundation for what is known as psychoanalysis, which for many is closest to spirituality, to what medical science can approach.

The error of praxis is a consequence of misconception, because with the advent of the specialties, time did not help at all, just the opposite of what was believed, in fact they could not serve for a better study of the parts, i.e. to have a better vision of the whole, but would turn, like almost everything touched by man, into something selfish and sectarian.

We would see then, how the society itself raised the specialist doctors to ranks that varied according to the importance of the organ they treated. The cusp is reserved for the neurosurgeon and the cardiologist, because we were taught that those are the «important» organs, and at the wide base is the dermatologist, for considering of less importance the one who takes care of the health of our skin, organ that certainly represents the first window to a diagnosis of health, as clearly expressed by Hippocrates more than 2,000 years ago, and whose famous description of an acute abdominal event, the facies hipocrátical, endures even today, after so much time, so much so that any medical student knows the phenomenon for its validity. As we can observe, such discrimination is found in the social imaginary: it is not based on something real.

We doctors indulged ourselves in being flattered by a society directed by the interests of the growing pharmaceutical industry, up to the point of thinking that we ourselves are those who heal, completely forgetting the precept of Berard and Gubler. Saying that medicine has lost its soul has never been more appropriate.

After my first fifteen years within this fearsome practice, and tired of attempting to search for the truth with limited success that medicine offers, I tried to find a different «truth». Being a physician with scientific opinions, I headed towards the search for a common denominator of that dismembered body, I did not take more than a few minutes to understand that I had it in front of my eyes: the cell. The pleasant surprise was to discover that famous scientists had already been devoting themselves to its study for not less than 60 years and had reached unimaginable developments in the understanding of its functions. One of them is Denham Harman (1), who in the 50s of last century dared to say that cell aging (damage) is a disease that could be reversed thanks to the discovery of free radicals and the harmful oxidative stress.

This gave rise to my interest in the cell regenerative medicine (CRM), because I understood that the cell was the key piece to dismantle the idea that the human being, in its broader context, must live while depending on a miraculous potion provided by pharmaceutical companies. No, the human being solely depends on their capacity of recovering one or more lost balances.

After the accumulation of knowledge in this field over the years, I have summed up what in my opinion is a complete view of the human being. My desire is to share how to maintain your health and always lead a full life.

II

Basic concepts of cellular physiology

The cell, as we all know, is the fundamental unit that constitutes all living organisms. It serves as a structure, but at the same time it fulfills thousands of functions at a speed that man has not yet been able even to approach to match.

To find out why some events happen in the organs we must first understand the physiology of the cell. What still remains a mystery for the biologists who fail to understand, is how can the cell use the same materials available, and only those (amino acids, vitamins, minerals, antioxidants, fatty acids, and carbohydrates), and achieve to combine them in such a way that the results produced are completely different like, for example, a digestive enzyme produced by the intestinal enterocyte in the gut, a hormone produced by a gland or a neurotransmitter, in the case of a neuron.

It is important to understand the cellular physiology –even through a rough but accurate description– in order to understand the points that we will discuss below. Let us examine its structure.

The cell is composed of three fundamental parts:

–Cell membrane

–Cytoplasm

–Nucleus.

Cell membrane. It presents a lipid bilayer structure formed by phospholipids which emit prolongations from the outside and from the inside, so creating a hydrophobic environment (which repels water), in middle membrane. The external and internal parts are hydrophilic i.e. they could allow the passage of water according to needs.

The cell membrane is crossed by protein structures that display ramifications of sugars (glycoproteins) toward the outside. We also find glucolipids (sugars added to fatty acids) and cholesterol, which is an important element, since with the presence of sulphur in its structure, it gives a large electromagnetic charge to the membrane, which has a relevant importance in the presence of a toxic metal, as we will see later.

The cell membrane works by controlling the passage of substances that reach its surface, selecting the ones needed for its metabolism (glucose, amino acids, fatty acids), also controlling the output of substances that may come from the residual discharge (water, urea, CO2, etc.) or active excretions of its specific function: hormones or enzymes.

It is important to remind that intracellular osmolarity must be the same as the extracellular, including the interstitial space, which is 301.2 mOsmol/L and 301.8, respectively. The fundamental difference is the inverse balance between sodium and potassium, with a higher presence of potassium inside the cell with a concentration similar to the one that sodium has outside of it (Na+ 114 mEq/l extracellular y K+ 144 mEq/l intracellular). Within the cell we find four times more protein, five times more phosphates, and the same amount of urea. Glucose is only found in the extracellular space, since its use is fleeting in order to get energy production by means of the Krebs cycle. Please consider that we have just come across the term balance right on starting the description of the minimum baseline of the cell.

Among the functions of the cell membrane, we can find:

–Transporting small molecules (ions) by active or passive mechanism,

–Receiving and transmitting chemical signals,

–Introducing substances through phagocytosis or pinocytosis,

–Delimiting the extracellular from the intracellular world.

–Interacting with the external environment actively.

Cytoplasm. It includes the internal components of the cell (nucleus, ribosomes, mitochondria, centrioles, vacuoles, inclusion bodies, centromeres, endoplasmic reticulum, lysosomes, Golgi apparatus) and where all the enzymatic and biochemical reactions typical of each cell type are performed. Its osmolarity and pH are essential to the proper functioning of these organelles.

a) Mitochondria, it carries out the well-known «cellular respiration», exchanging electrons in order to obtain the phosphorylated form of ATP to produce energy. Its importance is vital, so much so that it has its own DNA and ribosomes for the production of specific proteins. The dysfunction of this cellular organelle is responsible for the inflammatory pathologies that we will see later.

b) Endoplasmic reticulum: complex system of membranes that spans from the nucleus up to the very cell membrane. Its function is related to the synthesis of proteins (rugged ER, by the presence of large numbers of Ribosomes), lipids (smooth ER, it contains no Ribosomes). This is where the synthesis of lipids of the plasma membrane is centred, the cholesterol which will serve as a basis for the production of bile salts and steroid hormones.

c) Microsomes: small vesicle which is derived from the smooth ER and has a close relationship with the oxidation of xenobiotics through cytochrome P450.

d) Lysosomes: spherical structures with a single membrane that actively secrete enzymes that digest macro molecules to be used as an energy source. Moreover, they digest intracellular waste, microorganisms which have entered the cells. It is the lymphocyte basic defense mechanism.

e) Centrioles: they are structures that are activated during the division of the cell, their centromeres serve as poles of attraction for the chromosomes.

f) Ribosomes, they are active in the formation of proteins attached to the rough ER and scattered in the cytoplasm. They are composed of ribonucleic acid (RNA), their function is the renewal of tissues.

g) The Golgi apparatus: purely for storage and emunctory functions. It sits near the nucleus. It excretes and transports substances such as hormones, lipids, water and it stores proteins that coming from the rough ER.

h) Vacuoles: organelles for the storage of all kinds of substances, both cellular internal metabolism and those coming from the extracellular space.

i) Cytochrome P450: I must enphasise this family of heme proteins for their importance within the cell function in the «functionalization», i.e. modification of xenobiotics (2). They are located in a greater number in liver cells, close to the endoplasmic reticulum and the microsomes. Their function, as you will have observed, is to eliminate all substances that get inside the cell and do not provide any energy or structural benefit, nor for enzymatic function.

Nucleus. The importance the nucleus deserves is for being the reservoir of genetic information that encodes cell functions, and consequently the whole body through each apparatus, each organ each system. The nucleus cosists of:

–Nuclear membrane

–Nucleolus

–Nucleoplasm or karyolimph

–Chromosomes

a) Nuclear membrane: it presents pores that allow communication with the endoplasmic reticulum where the transcripted RNA of DNA is received, in order to reverse this information into the formation of a protein of the ribosome. The pores are not simple openings. Rather, they are formed by a complex of proteins with specific tasks called nuclear pore complex ( NPC).

b) Nucleolus: it constitutes the active centres for the production of proteins and RNA, which, in turn, consist of small molecular weight RNA.

c) Karyolimph: a liquid where nuclear structures remain suspended , its composition includes water, amino acids, RNA, carbohydrates, lipids and ions.

d) Chromosomes: they contain the genetic material to be transferred, the DNA. They are composed of RNA, DNA, protein type histones and protamines. They contain the genes that control the physiology of the organism through the production of proteins with specific functions (enzymes, hormones, neurotransmitters, etc.).

Thus we understand that the cells have a specific function, to produce proteins which can be for their own use and maintenance as functional proteins with all kinds of activities that influence other cells which make up a unit, an organ or a system.

Cellular biochemical complexity of the activities is the reason why all the balances must be respected, the main of which is the energy balance, because it determines the beginning of all processes.

The first question we must ask ourselves is: where does the energy come from? The answer is simple: from outer space.

The real miracle of life translates into a pigment owned by the plant kingdom, chlorophyll. This pigment manages to capture photons (3) from cosmic radiation and by means of a bioelectric magnétic reaction (Calvin-Benson reaction) (4) it manages to fit carbon dioxide from the atmosphere and soil water, producing, as a result, a stable molecule: sugar.

This sugar is a produced «miracle», since plants have managed to trap the light quantum, as Einstein called it, and preserve it within a combination of carbon and hydrogen, using for its mobilization the wonderful molecule of phosphorus, that makes this shift thanks