Harith Rajagopalan is a medical doctor, entrepreneur and co-founder of Fractyl, a biotechnology company based in Lexington, Massachusetts. Fractyl's stated mission is to solve the global epidemic of type 2 diabetes, a disease that stands in the way of a long and healthy life for so many people. Dr. Rajagopalan’s work focuses on a better understanding of the root cause of the disease and how diet-related damage to the inner surface of the small intestine leads to insulin resistance. The company has developed a clinical procedure to rejuvenate the duodenal surface, which helps patients reverse or even halt the progression of their diabetes. In this in-depth interview, recorded at TEDMED, Dr. Rajagopalan explains how the minimally invasive treatment works and how it could give hope to millions of patients who view diabetes as a progressive condition. He shares his evolving understanding of dietary practices, such as fat consumption and fasting - and explains why birthday cake should play a role in our lives.FlexBeam red light therapyRecharge Health is offering a discount on the purchase of FlexBeam, the wearable red light therapy device which targets key parts of the body to improve sleep/treat injuries/sooth aches/pains.  Sale price US$369 (down from $449) + extra $10 off use code equinox  Sale ends Sept 21: 0259 I PST DoNotAgeDoNotAge.org is offering listeners to LLAMA a 10% discount on its range of products – NAD boosters, Sirtuin activators, senolytics and more.  Any health queries can be answered by emailing the team at hello@donotage.orgUse the code LLAMA at checkout. - Time-line Mitopure (a highly pure form of Urolithin A) boosts the health of our mitochondria – the battery packs of our cells – and improves muscle strength. Time-line is offering LLAMA listeners a 10% discount on its range of products – Mitopure powders, softgels & skin creams.  Use the code LLAMA at checkout-Support the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.