Whether you’re a professional athlete or someone who just wants to maintain muscle mass as you get older, mitophagy is a process we should all be focusing on. Prioritizing strategies that enhance mitophagy and promote muscle health can significantly contribute to a healthier and longer life. But what exactly can we do to promote mitophagy? Luckily, my guest today is an expert in the science of mitochondrial activation, and he’s sharing insights on the supplement that you need in your longevity routine.   I’m joined by Dr. Anurag Singh, and we’re diving into the realm of mitochondrial activation and its impact on muscle performance and health. We also shed light on the role of immunity in a healthy, long life, focusing on how mitochondrial health can rev up our immune systems. Dr. Singh also shares his insights on how mitochondrial health can influence skin health and reverse sun damage, and the development of topical formulations that can improve mitochondrial health in the skin.   Dr. Anurag Singh is the Chief Medical Officer at Timeline Nutrition.    Thank you to our sponsors for making this episode possible:   Timeline is offering 10% off your first order of Mitopure. Go to timelinenutrition.com/NAT10 and use code NAT10 to get 10% off your order.   Paleovalley: Try my go-to snacks, the Paleovalley beef sticks. Head to paleovalley.com/nathalie to save 15% on your order. Berkeley Life: Consumers may register and place an order using my code NIDDBL for 10% off at berkeleylife.com Profound Health: Use code longevity15 to save 15% off your first order at https://profound-health.com/   Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08   Find more from Dr. Anurag Singh: Website: https://www.timelinenutrition.com/ Instagram: @timelinenutrition   What we discuss: (0:00:00) - Mitochondrial activation and muscle performance (0:12:13) - Revving up immune health through mitochondria (0:15:24) - Mitochondrial health and immune function studies  (0:21:06) - The benefits of high-dose vitamin c  (0:26:20) - Skin aging and mitochondrial health (0:27:53) - Topical formulation and skin health  (0:33:22) - Supplement industry quality and safety   Key Takeaways: The muscle is the most metabolically active organ in our body. It both produces and consumes the most energy currency, ATP. This is because even small movements like getting up from a chair or climbing stairs require a significant amount of energy. Activating mitophagy, the process by which damaged or dysfunctional mitochondria are selectively removed, has been shown to have significant positive effects on muscle performance. By selectively eliminating these damaged components, it allows for the generation of new and healthy mitochondria, thus enhancing muscle function.  Maintaining a healthy immune system can directly impact our overall health and lifespan. Immune cells, just like muscle, brain, and heart cells, contain numerous mitochondria. These mitochondria play a crucial role in supporting the high energy demands of immune cells.