Welcome back to another episode of the Incubator Podcast, where we continue exploring the management of respiratory distress in neonates. In this episode, we have the pleasure of welcoming back Dr. Lonnie Miner, who brings his wealth of knowledge in neonatal respiratory care to our ongoing discussion.Dr. Miner dives into the critical topic of weaning neonates from invasive ventilation, he discusses the need for standardized extubation guidelines, sharing insights into the criteria for successfully transitioning from high-frequency ventilation to conventional methods, and ultimately, to non-invasive supports. The conversation also covers the nuanced differences in managing various neonatal pathologies, highlighting the importance of individualized care. An interesting aspect of this episode is the exploration of different non-invasive ventilation modalities post-extubation, such as CPAP, nasal IMV, and NAVA. Dr. Miner provides a detailed analysis of each method, discussing their advantages, limitations, and appropriateness for specific clinical scenarios. He stresses the importance of understanding and being consistent with the chosen method, ensuring it meets the baby's physiological needs.As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!