In this episode of “At the Bench” in the Incubator podcast family, Dr. Donna Ferrero discusses her work on therapeutic hypothermia and neonatal brain injuries. She explains the development and implementation of therapeutic hypothermia as a treatment for brain injuries in newborns. Dr. Ferrero also explores the signaling pathways and early markers that can help identify patients who will respond well to hypothermia. She discusses the use of erythropoietin (EPO) and the results of the HEAL trial. Additionally, Dr. Ferrero highlights the importance of genetic variants and sex-specific differences in understanding and treating brain injuries. She also emphasizes the need for a multi-omics approach to better comprehend the complexity of brain injuries and develop personalized interventions. We also delve into the future of care for hypoxia ischemia and the importance of collaboration and career development for physician scientists. The value of collaboration with international researchers and the benefits of visiting other institutions and labs are highlighted. Tips for effective collaboration and overcoming challenges in career development are provided, along with insights into the role of leadership in advancing the field. As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!