Can you imagine the world of neonatal medicine from the lens of cutting-edge research and innovative practices? This week, we unpack the complexities of neonatal care, shining a light on the vital role of antibiotic prophylaxis in preventing secondary kidney damage for infants with severe VUR. We review a landmark study published in the New England Journal of Medicine, focusing on the use of continuous antibiotic prophylaxis for infants with severe vesicoureteral reflux. Not stopping there, we dissect the methodology, delve into the results, and ponder on the implications of this ground-breaking research.We also enter the intriguing realm of neonatal sepsis and enteral feeding in very low birth weight infants. Using guidelines from pediatricians and nephrologists, we scrutinize perinatal risk factors and the captivating findings of a meta-analysis published in the Journal of Maternal, Fetal and Neonatal Medicine. We explore the discrepancy between ordered vs administered enteral feeds, and the crucial need to include the entire NICU team to achieve better outcomes.In the final chapters, we tackle the tough topic of neurodevelopmental outcomes following preterm birth and the associated challenges in prognosis delivery. You'll hear from recent paper discussing insightful views on delivering prognoses and balancing clinical and epidemiologic reasoning with clear communication. Join us as we weave through the intricate tapestry of neonatal care, illuminating the long-term consequences of extreme premature birth and exploring the perspectives of those with firsthand experience of prematurity. Tune in to this enlightening and educational journey into neonatal care on The Incubator. As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!