Patrick and Greg draw on their experience in author, reviewer, and editorial roles to talk about the manuscript review process, and offer strategies for revising a manuscript and crafting a letter in response to editorial guidance and reviewer feedback. Along the way they also discuss spring break for octogenarians, spitting on graves, being flabby and unfocused, Milo and Otis, meat on a stick, subway jumpers, understanding square roots, voodoo dolls, ugly babies, Klingons, hostage negotiators, and rejected rejections.