In this episode Greg and Patrick wander semi-drunkenly around the topic of model-based inference and discuss how this perspective can help move us forward as a scientific discipline. They also somehow manage to discuss explosives, sniffing glue, homemade 787s, catfish noodling, the Ikea helpline, Calvinball, Ludwig Beethoven, Rube Goldberg, hell's half acre, denouements, and intolerable hypocrisy.