Brain-Gut Interactions And Somatization in Irritable Bowel Syndrome (IBS)

By Andrew Low

Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction defined by recurrent and longstanding abdominal pain and disturbed bowel habits. This book aims to deepen the knowledge about aberrant visceral sensory processing seen in a large group of patients with IBS, focusing on central mechanisms.

Anxiety, depression, and somatization are all associated with increased pain intensity ratings in hypersensitive IBS patients. Non-painful intensity ratings are influenced only by fear and to the same extent in regular- and hypersensitive IBS patients. Somatization is further associated with several measurements of rectal pain sensitivity and mediated the effects of depression and GI-specific anxiety on rectal pain perception. Sex, age, and sexual abuse in adulthood are also associated with rectal pain sensitivity.

The level of somatization in IBS is related to differences in local gray matter network connectivity, mainly in regions of the prefrontal cortex, insula, and cerebellum.

In conclusion, somatization, measured as multiple somatic symptoms, is essential for visceral (hyper-) sensitivity in IBS and is associated with altered structural connectivity within the brain.

• Language: English
• Publisher: vincenzo nappi
• Release date: Aug 28, 2021
• ISBN: 9798201563967

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TABLE OF CONTENTS

TABLE OF CONTENTS

ABBREVIATIONS

DEFINITIONS IN SHORT

INTRODUCTION

IRRITABLE BOWEL SYNDROME

PATHOPHYSIOLOGY

SENSORY TRANSMISSION OF THE GI TRACT

RECTAL SENSITIVITY TESTING USING RECTAL BAROSTAT

NEUROPLASTICITY

FUNCTIONAL NEURO-ANATOMY

BRAIN IMAGING IN IBS

SOMATIZATION OR CENTRAL SENSITIZATION?

CENTRAL SENSITIZATION IN IBS

WHICH PAIN PATHWAYS ARE INVOLVED IN IBS?

PAIN THRESHOLDS VS PAIN INTENSITY RATINGS?

IBS SUBGROUPS NOT RELEVANT?

WHAT ABOUT ABUSE?

ABUSE AND SYMPTOMATOLOGY

HIPPOCAMPUS, AMYGDALA AND CINGULATE CORTEX = MEMORIES, FEAR AND STRESS IN IBS HIGH SOMATIZATION?

INCIDENTAL FINDINGS AND NEUROETHICS

CLINCAL RELEVANCE

FUTURE PERSPECTIVES

CONCLUSION

ABBREVIATIONS

DEFINITIONS IN SHORT

INTRODUCTION

The brain is a fascinating place, a piece of jelly of about 1.3 kilograms where we experience the world. Within the brain emotions, affections, goals