Arterial Blood Gas Interpretation – A case study approach
By Mark Ranson and Donna Pierre
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About this ebook
With a strong focus on patient care pathways and including the most up-to-date information on arterial blood gas interpretation, this book will be invaluable to nurses, junior doctors and biomedical scientists as well as students and trainees in all these areas.
Contents include:
• Introduction to acid-base balance
• A systematic approach to ABG interpretation
• Respiratory acidosis
• Respiratory alkalosis
• Metabolic acidosis
• Metabolic alkalosis
• Compensatory mechanisms
• ABG analysis practice questions and answers
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Arterial Blood Gas Interpretation – A case study approach - Mark Ranson
Suffolk.
1
Introduction to acid-base balance
Mark Ranson
The homeostatic control of hydrogen ion concentration in body fluids is an essential requirement for life – to defend the relatively alkaline environment required for the most efficient maintenance of body processes and organ function (Ayers & Dixon 2012). The degree of acidity or alkalinity of a solution is dictated by the pH (potential of hydrogen ion concentration). Large quantities of volatile acids are produced from cellular metabolism (mainly carbon dioxide – CO2), and non-volatile acids from the metabolism of fats and certain proteins. A robust system for the maintenance of plasma pH is therefore required to defend the alkaline environment in the face of this massive, daily acid load.
An acid, by definition, is a substance that can donate (give up) hydrogen (H+) ions. A strong acid donates a lot of hydrogen ions, while a weak acid will donate only a few. An alkaline (or base) is a substance that can accept (take up) H+ ions. Like an acid, a strong alkali can accept a lot of H+ ions, while a weak one can only accept a few. The pH is related to the actual H+ concentration. A low pH corresponds to a high H+ concentration and is evidence of an acidosis. Conversely, a high pH corresponds to a low H+ concentration, known as an alkalosis (Edwards 2008). The interrelationship between oxygen (O2), H+, CO2 and bicarbonate (HCO3–) is central to the understanding of acid-base balance. It also reflects the physiological importance of the CO2/HCO3– buffer system, as illustrated in Figure 1.1 (below).
Figure 1.1 The interrelationship between H+, CO2 and HCO3– in acid-base balance
Mechanisms that maintain normal pH values
Maintenance of plasma pH within the range 7.35–7.45 is an essential requirement for life because many metabolic processes (such as enzymatic reactions) are extremely sensitive to changes in H+ concentration. Intracellular H+ concentration is higher (around pH 7.00) than that in extracellular fluid (ECF), but is sensitive to changes in extracellular H+ concentration. In terms of total volatile acid production, CO2 provides the largest contribution at 15–20mmol/day. This can occur either by the hydration of CO2 to form the weak, volatile carbonic acid or by hydroxylation of CO2 following the splitting of water. The products of both of these reactions are H+ and HCO3-.
Non-volatile acids contribute much less to daily acid production. Such acids include sulphuric acid from sulphur-containing amino acids, hydrochloric acid from cationic amino acids and phosphoric acid from the metabolism of phospholipids and phosphorylated amino acids. The contribution of non-volatile acids to daily acid production depends on dietary intake. If meat is a major component of the diet, non-volatile acids are significant (about 50mmol/day), whereas this is much lower if the diet is mainly composed of fruit and vegetables (Rogers & McCutcheon 2013).
Three basic mechanisms exist in order to defend and maintain the pH within functional parameters:
Physicochemical buffering
Respiratory compensation
Renal compensation.
Physicochemical buffering takes place via the main buffer systems in body fluids. These include: plasma proteins, haemoglobin and bicarbonate in the blood; bicarbonate in the interstitial fluid; and proteins and phosphates in the intracellular fluid. These buffering mechanisms are instantaneous but only limit the fall in pH.
Respiratory compensation is rapid (taking place in minutes) and operates via the control of plasma partial pressure of CO2 (pCO2) through changes in alveolar ventilation and subsequent excretion of CO2. Although this will allow the plasma pH to be returned towards normal values, this system cannot completely correct the acid-base balance.
Renal compensation is slower (taking place over hours or days) and operates via the control of plasma bicarbonate through changes in the renal secretion of H+, reabsorption and production of bicarbonate. This final mechanism facilitates complete correction of acid-base balance.
Normal blood gas values
Normal blood gas values for arterial and venous blood are shown in Table 1.1 (below). Arterial blood gas measurement provides an indication of the lungs’ ability to oxygenate the blood whilst venous blood gas measurement can give an indication of the efficiency of tissue oxygenation.
Table 1.1 Reference blood gas values
Key: kPa = kilopascals; MEq/l = milliequivalents per litre
The oxygen dissociation curve
The oxygen dissociation curve is a graph that shows the percentage saturation of haemoglobin (Hb) at various partial pressures of oxygen, as illustrated in Figure 1.2 (below).
Figure 1.2 Oxyhaemoglobin dissociation curve
The purpose of the oxygen dissociation curve is to show the equilibrium of oxyhaemoglobin and non-bonded haemoglobin at various partial pressures. At high partial pressures of oxygen, haemoglobin binds to oxygen to form oxyhaemoglobin. When the blood is fully saturated, all the red blood cells are in the form of oxyhaemoglobin. As the red blood cells travel to tissues deprived of oxygen, the partial pressure of oxygen will decrease. As a consequence of this, the oxyhaemoglobin releases the oxygen to form haemoglobin.
The shape of the oxygen dissociation curve is a product of binding of the oxygen to the four polypeptide chains. A characteristic of haemoglobin is that it has a greater ability to bind oxygen once a sub-unit has bound oxygen. Haemoglobin is therefore most attracted