This week Dr. Kahn was overloaded with important new science and discussed the risks of early menopause in women and the dangers of low testosterone levels in men. A concerning report on a rise in early colorectal cancer under age 45 is discussed. Two headline studies on the weight loss drug Wegovy (semiglutide) improving weight long term and improving heart failure measurements are hopeful. A massive "umbrella review" reported lower heart and cancer risks with plant-based diets. The main topic is about the implications of the coronary artery calcium score (CACS), in this case in healthy people over age 75. The CACS may be the best test of "biological age" available as the new study reports.