Nasal mupirocin plus chlorhexidine baths in ICUs prevents methicillin-resistant Staphylococcus aureus (MRSA) infections but raises concern about antibiotic resistance. JAMA Senior Editor Kristin Walter, MD, speaks with Susan Huang, MD, of University of California, Irvine, about a study comparing iodophor vs mupirocin with chlorhexidine bathing for ICU-attributable S aureus clinical cultures. Related Content: Nasal Iodophor Antiseptic vs Nasal Mupirocin Antibiotic in the Setting of Chlorhexidine Bathing to Prevent Infections in Adult ICUs