In this interview, Dr. Susy Hota and Dr. Susan Poutanen explain fecal microbiota transplantation as an effective treatment for recurrent Clostridium difficile infection. They also explain risk management and proper administration of the treatment, and how the medical field is starting to explore this treatment option for other diseases.Dr. Susy Hota is medical director of Infection Prevention and Control at the University Health Network in Toronto and assistant professor in the Department of Medicine at the University of Toronto.Dr. Susan Poutanen is a Medical Microbiologist and Infectious Diseases Physician at Sinai Health System and University Health Network and an associate professor at the University of Toronto.They co-authored a CMAJ article titled "Five Things to Know About...Fecal microbiota transplantation for recurrent Clostridium difficile infection." Full practice article: www.cmaj.ca/lookup/doi/10.1503/cmaj.171454Podcast transcript: https://www.cmaj.ca/transcript-171454-----------------------------------Subscribe to CMAJ Podcasts on Apple Podcasts or your favourite podcast app. You can also follow us directly on our SoundCloud page or you can visit www.cmaj.ca/page/multimedia/podcasts.