In this interview, Dr. Jennie Johnstone tells us about a strain of gram-negative bacteria called carbapenemase-producing Enterobacteriaceae (CPE) that is resistant to most antibiotics. She also discusses what the public and the health care system can do to help prevent the spread of drug-resistant organisms.Dr. Johnstone is infection prevention and control physician-scientist at Public Health Ontario and infectious disease specialist for St. Joseph’s Health Centre in Toronto. She co-authored a practice article in the CMAJ titled "Five things to know about...Emerging multidrug-resistant bacteria." Full practice article: www.cmaj.ca/lookup/doi/10.1503/cmaj.170110Podcast transcript: https://www.cmaj.ca/transcript-170110Subscribe to CMAJ Podcasts on Apple Podcasts or your favourite podcast app. You can also follow us directly on our SoundCloud page or you can visit www.cmaj.ca/page/multimedia/podcasts.