Bilateral renal agenesis results in lethal neonatal pulmonary hypoplasia. New evidence from an amnioinfusion trial is available. JAMA Deputy Editor Linda Brubaker, MD, MS, discusses the results from the Renal Anhydramnios Fetal Therapy Trial with Meredith A. Atkinson, MD, MHS, Johns Hopkins University, and Johnathan M. Davis, MD, Tufts University. Related Content: Neonatal Survival After Serial Amnioinfusions for Bilateral Renal Agenesis