Cervical cancer screening is effective when done as recommended. JAMA Deputy Editor Linda Brubaker, MD, speaks with Rachel L. Winer, PhD, MPH, of the University of Washington, about a recent trial in JAMA that compared cervical cancer screening strategies, including direct-mail and opt-in approaches for human papillomavirus (HPV) self-sampling. Related Content: Strategies to Increase Cervical Cancer Screening With Mailed Human Papillomavirus Self-Sampling Kits