In this episode, we talk to Professor Jon Emery, who is the Herman Chair of Primary Care Cancer Research at the University of Melbourne. Title of paper: The CRISP Trial: RCT of a decision support tool for risk-stratified colorectal cancer screeningAvailable at: https://doi.org/10.3399/BJGP.2022.0480Using risk models that account for family history, lifestyle and medical history could tailor CRC screening and determine starting age and screening test. This could be more cost-effective than population screening. In this RCT, we showed that using the CRISP risk tool in general practice can increase risk-appropriate CRC screening in those due screening. Its effect is more uncertain in patients who are up-to-date with screening. The CRISP intervention could be used in people in their fifth decade to ensure people start CRC screening at the optimal age with the most cost-effective screening test.