On this podcast episode, I discuss tamoxifen pharmacology, adverse effects, drug interaction, and much more.



Tamoxifen is converted to a more active compound in the body by CYP2D6.



CYP2D6 inhibitors such as paroxetine, fluoxetine, or bupropion can essentially reduce the effectiveness of tamoxifen.



Hot flashes are a common adverse effect of tamoxifen and I discuss a few pharmacologic options to manage this adverse effect.