On this podcast episode, I discuss vortioxetine pharmacology, adverse effects, drug interactions, and much more.



Because of vortioxetine's long half-life, antidepressant discontinuation syndrome is going to be less prominent compared to ADPs with shorter half-lives.



Vortioxetine is metabolized by CYP2D6. Drugs that inhibit this enzyme will likely raise concentrations and place the patient more at risk for adverse effects.



I discuss rare vortioxetine adverse effects like hyponatremia and bleeding in this podcast episode.