In this promethazine pharmacology podcast, I discuss its mechanisms of action, side effects, important drug interactions, and much more.



Promethazine has anticholinergic and dopamine-blocking activity which contributes to the adverse effect profile as well as its efficacy.



There is a boxed warning with promethazine to avoid the use of this medication in patients under the age of 2 due to respiratory depression.



Promethazine IV is considered a high-risk route of administration and should be avoided if possible.