Trazodone pharmacology is complex. It can inhibit serotonin reuptake, block histamine receptors, and possibly have alpha-blocking activity.



Side effects of trazodone include sedation, dizziness, and dry mouth. Rarely, priapism may occur. I've seen this nugget come up on pharmacology exams!



While trazodone is classified as antidepressant, it is often used to help manage insomnia.



Trazodone can possibly prolong the QT interval. Risk of other medications and patient specific parameters should be considered.



Trazodone concentrations can be increased with the use of CYP3A4 inhibitors and reduced with 3A4 inducers.