On this episode, I discuss the mechanism of action of the SGLT-2 Inhibitors and how they lower blood sugar.

These drugs are classically used for diabetes and eliminate blood sugar through the urine.

One of the potential side effects is that these drugs can increase the risk of genital infections and urinary tract infections.

There is a boxed warning on canagliflozin for its potential to increase the risk of amputation.

These drugs also have a mild diuretic type effect and can potentially cause hypotension.

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Eric Christianson, PharmD, BCGP, BCPS