12 min listen
Doxepin Pharmacology
FromReal Life Pharmacology - Pharmacology Education for Health Care Professionals
Doxepin Pharmacology
FromReal Life Pharmacology - Pharmacology Education for Health Care Professionals
ratings:
Length:
14 minutes
Released:
Jan 9, 2020
Format:
Podcast episode
Description
Doxepin is under the class of tricyclic antidepressants. It can inhibit the reuptake of serotonin and norepinephrine.
In addition to the serotonin and norepinephrine reuptake inhibition mechanism, doxepin also has antihistamine type effects.
Because of the anticholinergic activity of doxepin, it is recommended to avoid this medication in the elderly, particularly at high doses.
Be aware that anticholinergics like doxepin can reduce the benefit of dementia medications.
CYP2D6 is an important enzyme in the metabolism of doxepin and drugs like bupropion that inhibit CYP2D6 can increase the concentrations of doxepin.
In addition to the serotonin and norepinephrine reuptake inhibition mechanism, doxepin also has antihistamine type effects.
Because of the anticholinergic activity of doxepin, it is recommended to avoid this medication in the elderly, particularly at high doses.
Be aware that anticholinergics like doxepin can reduce the benefit of dementia medications.
CYP2D6 is an important enzyme in the metabolism of doxepin and drugs like bupropion that inhibit CYP2D6 can increase the concentrations of doxepin.
Released:
Jan 9, 2020
Format:
Podcast episode
Titles in the series (100)
NSAID Pharmacology RLP Episode 008: In this podcast episode I discuss the pharmacology of NSAIDs and the potential collateral damage that can result from these medications. We'll cover: Side effects Mechanism of Action Important Drug Interactions by Real Life Pharmacology - Pharmacology Education for Health Care Professionals