Juvenile idiopathic arthritis and lupus are the most common rheumatic diseases in children. However, more than 500,000 children develop other rheumatic diseases. The diagnosis, treatment, and management of these conditions often require a multidisciplinary approach owing to the diverse clinical manifestations that present in this patient population. In light of Rare Disease Day 2022, we spoke with Emily von Scheven, MD, a pediatric rheumatologist at the University of California San Francisco Benioff Children's Hospital and the executive committee chair of CARRA, and Vincent Del Gaizo, director of partnerships and patient engagement for CARRA and a parent of a pediatric patient with rheumatic disease.