There were several interesting research papers, posters, abstracts, and presentations on the diagnosis and treatment of lupus at the American College of Rheumatology (ACR) Convergence 2021, including the Great Debate that was about the use of voclosporin vs belimumab as add-on therapy in lupus nephritis. Karen Costenbader, MD, provides a comprehensive roundup of all the exciting and compelling news and research in lupus, as presented at ACR annual meeting.